2 better than 1?

There is enough evidence to suggest that lowering LDL cholesterol helps decrease the incidence of coronary artery disease. It is a bit of a surprise therefore to learn from the ENHANCE trial that a greater degree of LDL cholesterol lowering with the combination of Ezetimibe and Simvastatin, when compared to Simvastatin alone, did not have any significant impact on the carotid intima-media thickness.

The IMPROVE IT trial is now underway to study if this combination of Ezetimibe and Simvastatin will be better than Simvastatin alone in reducing cardiovascular events.

For now, there is no evidence to recommend that the combination of ezetimibe plus simvastatin is better than a statin alone for patients with elevated LDL cholesterol levels.

Note:
Exetimibe is a drug that lowers LDL cholesterol by reducing intestinal absorption of cholesterol.

Simvastatin is a drug that lowers LDL cholesterol by affecting a key enzyme in the liver.

Carotid intima-media thickness is a marker of atherosclerosis in the carotid artery.