Reference: The Lancet
Tuesday, July 27, 2010
Saturday, May 8, 2010
Lung cancer (teratment)
- The treatment of lung cancer is dependent on the type and stage of cancer.
- The treatment explained here is only a summary:
1) Non-small cell lung cancer
* Stages IA, IB, IIA, IIB & some IIIA :
- basically the tumour is resected with / without removal of the lymph nodes in the mediastinum.
- post-operative radiotherapy is only advocated for selective patients.(with N2 disease if no neoadjuvant chemotherapy)
* Stage IIIA & IIIB
- The treatment for this stage of lung cancer is a little more complicated in that it depends also on the nature of the tumour i.e. bulky, with/without chest wall invasion,etc.
- It is suffice to say that resection of tumour is followed up with chemotherapy or radiotherapy.
* Stage IV & more advanced IIIB
- For this stage, radiotherapy to site of the involved area for relieve of symptoms.
- Chemotherapy for ambulatory patients.
- Resection of primary tumour and tumour spread (metastases) will be considered.
2) Small cell lung cancer
- limited stage (good performance status) : chemotherapy + chest radiotherapy
- Extensive stage (good performance status) : combination chemotherapy
- complete tumour responders (all stages) : consider prophylactic cranial radiotherapy
- Poor-performanc-status patients (all stages) :modified-dose combination, palliative care.
3) All patients
- radiotherapy for brain metastases, spinal cord compression, weight bearing lytic bony lesions, symptomatic local lesions.
- encourage to stop smoking.
- supportive care during chemotherapy.
- The treatment explained here is only a summary:
1) Non-small cell lung cancer
* Stages IA, IB, IIA, IIB & some IIIA :
- basically the tumour is resected with / without removal of the lymph nodes in the mediastinum.
- post-operative radiotherapy is only advocated for selective patients.(with N2 disease if no neoadjuvant chemotherapy)
* Stage IIIA & IIIB
- The treatment for this stage of lung cancer is a little more complicated in that it depends also on the nature of the tumour i.e. bulky, with/without chest wall invasion,etc.
- It is suffice to say that resection of tumour is followed up with chemotherapy or radiotherapy.
* Stage IV & more advanced IIIB
- For this stage, radiotherapy to site of the involved area for relieve of symptoms.
- Chemotherapy for ambulatory patients.
- Resection of primary tumour and tumour spread (metastases) will be considered.
2) Small cell lung cancer
- limited stage (good performance status) : chemotherapy + chest radiotherapy
- Extensive stage (good performance status) : combination chemotherapy
- complete tumour responders (all stages) : consider prophylactic cranial radiotherapy
- Poor-performanc-status patients (all stages) :modified-dose combination, palliative care.
3) All patients
- radiotherapy for brain metastases, spinal cord compression, weight bearing lytic bony lesions, symptomatic local lesions.
- encourage to stop smoking.
- supportive care during chemotherapy.
Tuesday, April 6, 2010
Tuesday, March 23, 2010
Monday, March 15, 2010
Tuesday, March 9, 2010
Lung cancer (Histological classification)
Bronchogenic carcinomas of primary lung cancers can be classified as follows:
o Non small cell lung carcinomas (NSCLC) : This accounts for 70 -75% of bronchogenic carcinomas and can be further subdivided into:
§ Squamous cell carcinoma (25-30%)
§ Adenocarcinoma (30-35%)
§ Large cell carcinoma (10-15%)
o Small cell lung carcinoma (SCLC) : This chalks up 20 – 25% of bronchogenic carcinomas and comprises mainly of a group of cancers called oat cell carcinomas.
o Combined patterns : this consists of the various types of combinations of NSCLC and SCLC e.g. combined squamous & adenocarcinomas and combined squamous cell carcinomas & SCLC.
Friday, February 19, 2010
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